My lecture examines the philosophical and theological underpinnings of transhumanism, a movement that advocates for the use of technology to enhance human abilities and transcend biological limitations. Drawing on the concept of Gnosticism, which posits that salvation (or: liberation, elevation, fulfillment) comes through secret knowledge or gnosis and that the human bodily existence is to be overcome as something inherently limiting, low, and detestable, I argue that transhumanism can be seen as a form of techno-Gnosticism. Transhumanists, like Gnostics, seek to transcend the limitations of the material world through the acquisition of knowledge and the manipulation of reality. In my lecture, I explore the implications of this perspective for our understanding of human nature, ethics, and spirituality, and argue that it raises important questions about the relationship between technology and human flourishing. Ultimately, I contend that while transhumanism offers tantalizing possibilities for human enhancement, it also carries significant risks and challenges that must be carefully considered in any attempt to pursue a transhumanist future.